We Functionalize Heterocycles

 

One of the goals of the McNally group is to develop facile and reliable methods to selectively modify pharmaceuticals, materials and agrochemicals. Our group explores the use of phosphonium salts as a functional handle to create valuable products.  Phosphonium salts have shown to be reliable precursors for the formation of C-C, C-N, C-O and C-S bonds with applications in late-stage functionalization.  Their relative ease in purification and the use of inexpensive materials make these salts an increasingly attractive class of molecule in synthesis. 

 
 

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